It’s More Than Stamp Collecting: How Genome Sequencing Can Unify Biological Research
Identifieur interne : 000099 ( Main/Exploration ); précédent : 000098; suivant : 000100It’s More Than Stamp Collecting: How Genome Sequencing Can Unify Biological Research
Auteurs : Stephen Richards [États-Unis]Source :
- Trends in genetics : TIG [ 0168-9525 ] ; 2015.
Abstract
The availability of reference genome sequences, especially the human reference, has revolutionized the study of biology. However, whilst the genomes of some species have been fully sequenced, a wide range of biological problems still cannot be effectively studied for lack of genome sequence information. Here, I identify neglected areas of biology and describe how both targeted species sequencing and more broad taxonomic surveys of the tree of life can address important biological questions. I enumerate the significant benefits that would accrue from sequencing a broader range of taxa, as well as discuss the technical advances in sequencing and assembly methods that would allow for wide-ranging application of whole-genome analysis. Finally, I suggest that in addition to “Big Science” survey initiatives to sequence the tree of life, a modified infrastructure-funding paradigm would better support reference genome sequence generation for research communities most in need.
Url:
DOI: 10.1016/j.tig.2015.04.007
PubMed: 26003218
PubMed Central: 4490122
Affiliations:
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